Making Sense of the Expanding Molecular Toolbox for Skin Cancer Diagnosis-Diagnostic Utility of Mass Spectrometry Imaging in Melanocytic Lesions

Diagnostic Utility of Mass Spectrometry Imaging in Melanocytic Lesions

Video Transcription

Video Summary

Rusica Lozova discusses the diagnostic utility of mass spectrometry imaging in melanocytic lesions. Proteins play a vital role in cellular function, and genetic alterations are key in carcinogenesis. Mass spectrometry imaging measures peptides directly, providing information on protein translation and modifications. The method involves applying matrix to tissue sections, using a laser to evaporate molecules, and obtaining mass spectra based on their speed and charge. The technique can differentiate between benign and malignant lesions, aiding in accurate diagnoses and predicting clinical outcomes. Mass spectrometry proved reliable in distinguishing between nevi and melanomas with high accuracy. It can classify lesions based on proteomic differences and assist in challenging cases. Further research is warranted to refine diagnoses and validate findings. Mass spectrometry imaging is a valuable tool in diagnosing melanocytic lesions accurately, objectively, and affordably.

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Rossitza Lazova, MD

Keywords

mass spectrometry imaging

melanocytic lesions

proteins

genetic alterations

protein translation