Navigating Clinical Trials: Essential Knowledge for Dermatologists-Hidradenitis Suppurativa Clinical Trials: Tips and Tricks

Hidradenitis Suppurativa Clinical Trials: Tips and Tricks

Video Transcription

Video Summary

Alexa Kimball, a Harvard Professor of Dermatology, discusses conducting clinical trials for Hidradenitis Suppurativa, a chronic skin condition. Over 15 years, the field has evolved from lacking standardized outcomes to having well-established methods. Key considerations include endpoint selection, sample size, placebo rates, eligibility criteria, and concomitant treatments. Current scoring systems like the HiSCR focus on nodules and abscesses and omit fistulas, leading to ongoing development of more comprehensive scoring. Clinical trials are shifting towards active control studies and utilizing platform designs to minimize placebo use. Strategic study design, including consistent grading and addressing patient variability, is crucial for effective trials.

Asset Subtitle

by Alexandra Kimball, MD, MPH, FAAD

Keywords

Hidradenitis Suppurativa

clinical trials

HiSCR scoring

platform designs

patient variability